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MX, SX & Off-Road Discussions
General Moto | Off-Topic Posts
Anyone ever heard of Chondromalacia(knee cond.)
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[QUOTE="nephron, post: 135164, member: 23759"] Yeah, Vioxx and Celebrex are the COX-2 inhibitors. Traditional NSAIDS (nonsteroidal antiinflammatory drugs) such as aspirin, ibuprofen, naproxyn sodium, piroxicam, etc. block both COX-1 & COX-2. (COX is not a pseudonym for male genetalia ;) but stands for cyclooxygenase, the main pathway mediating inflammation). When COX-2 inhibitors came out, they promised stomach "safety", because traditional NSAIDS block prostaglandin production in the GI tract, resulting in increased risk of gastrointestinal hemorrhage, ulcers, gastritis, etc. However, analysis of level 4 testing these days shows they cause damn near as much NSAID associated antral ulcers as traditional NSAIDS. There's a whole lot more to this story, but I won't bore you with it. Suffice it to say that I had to reprimand Drug Reps :( and contact the companies themselves because I was seeiing a lot of Acute Renal Failure and Salt Retention. They are currently being overused, and there's been a transition bias of complications accreduted ti COX-2 inhibitors. The good news is that A) complications are rare, particularly in young folks with normal renal function and B) By specifically blocking COX-2, I believe they work better than traditional NSAIDS. At least that's been my experience thus far. Bottom line: Vioxx/Celebrex are great drugs for the right people, and work particularly well for musculoskeletal pain and headaches. Problem is--when your doc runs out of samples, you'll really enjoy paying about 4 bucks a pill, as a script runs 120 bucks a month. :scream: :silly: Jack [/QUOTE]
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MX, SX & Off-Road Discussions
General Moto | Off-Topic Posts
Anyone ever heard of Chondromalacia(knee cond.)
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