hey mike, the big bores like 40:1 with a good oil like a semi
synthetic.
all the manuals in the old days say 20:1 because the oil sucked back then, oil technology has advanced a lot since
your bike will run much better and resist plug fouling with 40:1
with todays great selection of oils even 32:1 can be to much oil
the oils these days are rated good and safe right up to 50:1
as for the jetting, keep it stock unless you have significant performance issues it's best left alone.
don't idle or drive slow for long periods of time on your bike
its best when you keep a load on the engine so the plug stays in the self cleaning temperature range