I ran it in the past and never noticed any throttle response issues. Maybe I'm just not as sensitive to these things as some, or maybe pump gas is so lousy these days that the throttle response is just as bad using it. Regardless, if you're looking for a cheap highish octane fuel I wouldn't rule out 100LL Blue. Though as Okie said it would be handy to know why you're asking. If you just need the cheapest solution to a detonation problem the 100LL may be an option (though in the long run having the head modified to sort out the problem would be cheaper again), but if you're looking to build a motor to get maximum horse power you'd be better off aiming for one of the appropriate race fuels.