dales298 said:
If you mix two different oils together you are asking for a fouled plug.
Dale
Unless you are mixing significantly different oils, this unlikely. Virtually all modern oils mix without issue, unless you are trying to mix castor and synthetic or something. It is better to use the same oil for consistency though.
Poor jetting causes way more fouled plugs than the oil used, or the mix ratio used.
As to whether you can adjust your mix ratio and play with the air screw. No it will not lean it out. Going to 40:1 will actually richen the jetting slightly, and make your problem worse, not better. The air screw will only lean out the pilot circuit, not the needle, or mains, so no, you have to rejet the bike properly to solve this problem.
Get some fresh mix with only one type of oil, a box of plugs, and jets a couple sizes smaller than what is in there now, and start tuning until it is correct. There are very good instructions floating around here on how to correctly jet your bike, run a search, find them, and then tune your bike from there.