One of the main keys to your bike is having the jetting set up - are you currently fowling plugs? If so you are running rich(two smokes don't fowl plugs if jetted correctly) the bike needs to be jetted properly. I run Motul and mix it 50:1. Keep in mind though - every bike in it's enviroment(primarily altitude) will equire something different. It's safe to say though running 40:1 is ok.
This is just a very basic framework though, but will atleast get you by.