As far as what route to take, you could go PA turnpike to I-70W through WV, OH, IN, IL to St. Louis then I-55 to I-44 then get on I-40W in Oklahoma. BUT, I would do as Indy said and take PA turnpike to Carlisle, PA and get on I-81 South. This follows the Shenandoah Valley down through Virginia into TN. 81 runs right into I-40W near Knoxville. 40 will take you all the way to AZ. This is slightly longer than going I-70 but much more pleasant. Beautiful scenery, much smoother roads (at least until Arkansas) and fewer large cities and traffic jams. I live in Reading PA and have taken both routes many times. I much prefer the southern route. Also, this may save you some trouble- get in the habit of checking your vehicle and your load every time you stop. Thump the tires, check marker lights, hitch and connections, look under trailer. Get inside trailer and check straps, look for stuff rubbing together, etc. You'll be surprised how much damage you can avoid this way. Hope this helps. Have a good trip.