Three tales of plugs and fouling:
I have a two stroke outboard, 9.9 HP. In the 15 years that I have owned the outboard I have changed the plug once. I run 50:1 oil mix, whatever oil is cheap. The motor gets used a fair amount, and it always is operated under fairly heavy loads and up in the higher RPM range. It starts easy and will idle without stalling.
I run 40:1 synthetic oil (Motul 800) in my YZ-125. I have never fouled a plug to the point that it wouldn't run, but when I ride along with my wife on her quad I tend to "putt" and the responsivness of the bike just goes to hell. Every once in a while I have to get up and go for a minute or else it will start bogging so bad I can't stand it.
One of my riding buddies rides a Yamaha WR-250, two stroke, same oil mix, same plug. He has never had a problem (that I am aware of) when we were riding together. A couple of weeks ago we rode together in a club enduro, family oriented event. The enduro runs several loops, reusing previous sections a bit. They stagger the end points, sending the masters the farthest and the novices stopping the earliest. Once the deadline for the last rider has passed we all ride the course backwards, pulling all the arrow stakes and removing the ribbon from the bushes. It was a lot of slow riding, frequent stops, never getting up to speed.
We made it about two miles before my buddies bike just quit from a fouled plug.
If you want the performance from a two stroke then you need to work the engine hard enough to burn the deposits off the plug. If you are willing to "detune" (like my outboard is) then run a hotter plug it will tolerate putt'in around, but you will lose that peak performance.
Rod