It would be a huge step, IMO. I'd look into a CRF250, or the "X" model (woods). Although the X's are new and will be kinda pricey. I've got a TTR125 also, with every mod I can think of except the cam/big bore kit, and the difference between it and my 450 is huge. On the other hand, depending on how comfortably you could control that YZ250, and how judicious you are with the throttle, the 450 might work out. The power delivery is much smoother than the 2-stroke, but could still get away from you in a panic situation. Another issue is that the 450 will require considerably more basic maintenance than the TTR-oil and filter changes regularly, so be prepared for that. Hope this helps.