Although I have a powerstroke F250 Crew cab I feel that I can offer some issues to think about.
The powerstroke is a great motor, the version used in the vans are tuned to have less power than in the pickups. Even with the "de-tuned" version, it will flat out haul whatever you want down the road with ease. From my experience and from what I've read, the auto trans is the weak link in the drive train. My transmission went out after 1,000 miles. If your OD light on the gear shift lever starts to blink, take the vehicle to the dealer ASAP.
A couple of things that turbo deisels need is proper warm up and after highway crusing, proper cool down. Let that baby idle and warm up before you take off. After you pull off of the highway let the engine idle for 5 minutes or so and let the turbo cool down. This will add to its life. I'm not talking about around town driving but when you driving down the highway and the engine is pulling hard enough so the turbo is working. I used to pull my 16 foot trailer with a chevy 1/2 ton with a 350 engine. I would get 7 to 9 miles to the gallon depending on the terrain. I'll get 12 to 14 miles to the gallon with the powerstroke depending on terrain and how fast I go.
All in all I'd recommend the powerstroke in the van. It's more money but that baby will flat out cruise down the road.