At Dirtweek, I rode an '01 450EXC and an '02 400SX almost back to back. I really couldn't tell much difference. But I wasn't paying attention to the tranny. I think the only time you would notice a difference is if you're crawling in first gear or on an open stretch in high gear. The close ratio is more suited for acceleration through a more common distance (straights on a track, etc.). The wide ratio is more suited for changing conditions (offroad riding with first gear trails, and open areas with long straights.) I've always ran close ratio tranny bikes(except for the DRZ) because we don't have any open areas. Most of our trails are between 2nd and 4th gear trails. You'll also find yourself shifting more often with a C.R. tranny.
As far as the 300 vs. 380...I don't know. I've never ridden a 300, but the 380 I rode was a beast. I'd be on a 300 if I was riding a 2 stroke. I don't think there would be much similarity between the 300 and a YZ250.