With a lot of money in mods, probably. But if you are a fast rider and with your weight I'd look into something with a little more umph, like a KTM 300 or a woods-modified 250 motocrosser.
Mine is about as good as it gets engine-wise, it's good enough for me (180 lbs) in harescrambles, but leaves me wanting more on a track or when play riding on wider stuff.
Fredette Racing porting, modified head, bored carb
FMF rev pipe and Turbine Core II silencer
Boyseen reeds, modified airbox lid, and proper jetting.
2 teeth bigger on rear sprocket
It's like a fast 125 with lowend.
Doesn't the DRZ400 share the same engine with the Z400 quad? My buddy has a 2000 or 2001 Z400, now a 440, camed, different head, different carb, and a lot of other mods (I'm not for sure on the specs). That thing has a whole lot more motor than my bike. If your bike is simular to his quad I think you might be disapointed with the 220, especially a stock 220 (which is super super super mellow).