Hate to burst your bubble, but 2-R is a semi-synthetic, it even says that on the front of the bottle.
This is why I switched to Mobil-1 MX2T. Its a full synthetic that's cheaper than Yamalube 2R and I still mix it 40-1. I was a true believer in 2-R until I ran across MX2T.
i bought a pint of the 2R and their is nothing on any of the labeling that says it is semi or full synthetic oil.(maybe they changed the labeling?) So i will save it for the weedeater and chainsaw and mix it 32:1
My KTM manual suggests the full synthetic motorex cross power mixed at 60:1.
I think the important thing is to use the oil that your bike manual suggests, mixed at the oil gas ratio that the manual suggests. If the bike still does not run properly you then may need to clean the air filter or adjust the jetting in the carb to get the correct air/fuel mixture for your elevation/temprature.
Some of the oils like Amsoil say right on the label what the fuel/oil ratio should be mixed at. If the label says "MIX THIS AT 40:1" then don't mix it at 32:1 to save a few hours of wear on the motor......or 60:1 because your previous brand of oil mixed at that ratio. Trust what the manufacturer has tested to be the best mix for their specific type oil. Some oils have additives that will allow them to be mixed up to 100:1, other brands of oil will not. If you have been using Amsoil mixed it 100:1, you probably don't want to buy Yamalube 2R and mix it at 100:1 as you were the Amsoil. Just mix your fuel/oil at the manufacturers suggested mix ratio and you should not have any worries.