It really depends upon your skill level and what kind of riding you do.
If you race MX I would say that if you have the skill to use all the power your 250F has, then yes, go with the 450.
If you ride trails and want something that has more lowend grunt then I would also say yes go with the 450.
Just know that a 450 is heavier and can get away from you pretty easily if you dont have respect for the power.
Two completely different bikes. Depends on what your looking for and what you are going to use the bike for. Give us more details and we can give better advice.
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