That does sound bad but it can mean something... If there is no difference by moving that screw and it seems really lean possibly it could it be the rubber boot seal leaking either on the engine side or the airboxside. When you had the carb off did you notice any dust in the boot. maybe the carb boots are not sealing right or something poked a hole in the boot and when you open the slide the extra air and vacuum just really leans it out that could explain the headpipe getting so hot and getting lean at half throttle. I mean barring a clogged passage in the carb. If it was electrical would it heat up the headpipe like a lean condition I think the plug would be wet with gas from a weak or no spark. I would really look closely for a dust trail in the boot and check the boots for holes or nubs of rubber on the sealing surfaces and put black or copper silicone on the surfaces of the engine and airbox seals before reinstall. I would really check the side from the carb to the engine for holes in the boot or casting irregularities and make sure the carb is solidly in there with the notch in the boot aligning with the tab on the carb.